is tirzepatide dosing the same as semaglutide vs. for Weight Loss Switching from semaglutide to tirzepatide

For Salkin, the takeaway is not fear or alarm

Holst JJ, Physiol Rev 87:1409-39, 2007 Drucker FJ, Cell Metab 135-165, 2006 INSULIN SECRETION PKA IC Ca++ MOLECULAR ACTIONS OF GLP-1 ON BETA CELL Insulin Secretion cAMP Epac2 PI-3K INSULIN GENE TRANSCRIPTION Pdx-1 replenishes beta cell insulin stores prevents beta cell exhaustion BETA CELL GLUCOSE SENSITIVITY increased GLUT2 and Glucokinase restores glucose responsitivity to resistant beta cells INSULIN RESPONSES TO PHYSIOLOGICALAND PHARMACOLOGICAL LEVELS OF GLP-1 Pharmacological GLP-1 levels2(15 mM hyperglycemic clamp) Physiological GLP-1 levels1(15 mM hyperglycemic clamp) 6000 6000 GLP-1 infusion-0.5 pmol/kg/min GLP-1 infusion-1.0 pmol/kg/min Plasma GLP-1: 46 pM Healthy controls 4000 4000 Insulin (pmol/L) Insulin (pmol/L) Plasma GLP-1:126 pmol/L Type 2 diabetes 2000 2000 Plasma GLP-1:41 pM Type 2 diabetes 0 0 0 60 120 0 60 120 Time (min) Time (min) 1

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Wegovy should not be used by people with a personal or family history of medullary thyroid carcinoma, MEN 2, or serious allergy to semaglutide, and medical advice is required before use in pregnancy, breastfeeding, diabetes, kidney problems, pancreas problems, or before surgery

Its tablet form makes it easy to carry and take with meals when away from home