In an announcement of the study on the Vanderbilt website, lead author Khrysta Baig described this as a purely hypothetical scenario, but one that underscores that at current prices, these medications cannot be the only way or even the main way we address obesity as a society. In a more conservative estimate, Bhaig and coauthors consider a case where only about 10% of those eligible for obesity treatment opted for semaglutide, which would result in $27 billion in new costs
Chow ES, Long DM, Giebultowicz JM
This amount helps maintain glutathione in its active, "reduced" state and prevents it from being depleted too quickly by oxidative stress
This step conjugates cysteine with glutamate, generating -glutamylcysteine
At the time, we didnt fully understand how it reduced food intake, but it did