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However, the international SC reviewed statements to minimise this risk

The "half-step" approach: Some researchers soften the 2mg to 4mg transition by doing one week at 3mg before moving to 4mg

It may become important in future management of hyperaldosteronism/Conn-related hypertension

Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE