semaglutide and suicide A recent post hoc analysis published in Obesity found tirzepatide vs. placebo was not associated with increased risk of depression symptoms. Rates of suicidal ideation behavior were low and similar to Disproportionate' Suicide/Self-Harm Signal With Semaglutide:

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The most advanced of them, danuglipron, has demonstrated good efficacy in a twice-daily formulation, and we believe a once-daily formulation has the potential to have a competitive profile in the oral GLP-1 space," said Mikael Dolsten, MD., PhD., chief scientific officer & president, Pfizer Research and Development