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Recent data from the ATTAIN-MAINTAIN trial showed that patients transitioning to orforglipron after injectable GLP-1 therapy maintained their weight loss with minimal regain (approximately 0.9 kg after semaglutide transition), suggesting that oral maintenance strategies could minimize the lean mass depletion seen with prolonged high-dose injectable therapy

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DNAmFitAge: biological age indicator incorporating physical fitness

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The same concepts also apply to peptides and proteins, each of which will have a pI value that is influenced by the characteristics of its side chains