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Canagliflozin significantly inhibits inflammatory factor expression, including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase, exerting cardioprotective effects by regulating inflammation and ferroptosis through the AMP-activated protein kinase (AMPK) pathway (83)
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10.1021/acs.chemrev.7b00258 16 FergusonG
These complementary pathways create synergy when combined
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