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In this experiment, calibrated Von Frey filaments were employed to evaluate joint pain sensitivity as previously described 38,39 , the results showed that metformin treatment increased the paw withdrawal thresholds compared with those in MIA-induced OA model group (Fig
When antigens from food, bacteria, or toxins come into contact with mast cells, the cells release mediators that cause various physiological responses, including inflammation
2016;6:e967
S.ToledanoA
PMCID: PMC7563541
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