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It may upregulate growth hormone receptor expression in specific tissues such as tendon fibroblasts, which is a different mechanism from increasing systemic hormone levels
If a patient is truly deficient and cannot absorb oral B12, injections are lifesaving and the benefits outweigh the small risk
Co-localization was also performed due to the manufacturers protocols using Puromycin (Sigma, St Louis, MO) as a negative control and anti-HNE (ab48506) (Abcam, Cambridge, GB) (1:50) and anti-Pus7 (PA5-54983) (Thermo Fisher Scientific, Waltham, MA) (1:200)
A point to highlight is that the normal reference range needs to be interpreted with caution in cases of hemolysis, reticulocytosis, and for preterm infants, as these are associated with elevated enzyme levels
Biomed Pharmacother 2003;57(3-4):145-155
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