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These small differences in efficacy of BLX2477 may be explained by the 3-log higher IC 50 of BLX2477 for free versus PE-esterified eicosatetraenoic acid (ETE) (Supplemental Figure 3)
Preclinical and early-phase clinical studies suggest that certain natural supplements may modulate therapeutic response and influence treatment-related toxicity
Fast metabolizers clear caffeine 4060% faster than slow metabolizers.[50][51] Slow metabolizer allele frequency varies by ancestry: Source: Dalal et al., 2018[52]
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