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While the research base for microdosing, specifically, is still developing, and lower-dose protocols are being explored, though clinical evidence for efficacy at sub-therapeutic doses remains limited
The references below cite published preclinical research conducted in animal models and in vitro systems
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Disruption of IR impairs differentiation of chondrocytes in vitro We next examined the effect of deletion of IR on chondrogenic differentiation in primary chondrocytes
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