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The study included interviews with Ohio restaurant operators

Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA

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Specifically, Clostridium scindens (now known as Lachnoclostridium scindens ) is a pivotal functional species that mediates the conversion of primary bile acids into secondary bile acids via 7-dehydroxylation, thereby maintaining intestinal homeostasis and barrier integrity 181