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6.3 Oxidative stress and insulin resistance The Insulin Resistance (IR) explains the failure of muscles, fat, and liver to respond well to insulin and their incapacity to take up glucose from the blood
Waegeman H, Soetaert W
In addition, sitagliptin exhibited potent nephroprotective properties against the nephrotoxicity induced by methotrexate 32 , gentamicin 33 , acute IR injury 34,35 , and adenine-induced kidney disease in rats 36
Gastrointestinal issues: Conditions like Crohns disease, celiac disease, or a history of gastric bypass surgery can impair oral absorption
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