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Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels

B12 shots offer a full dose, all-at-once solution

Dose Adjustment Based on Response: Individual response to AOD-9604 varies based on factors including baseline body composition, metabolic health, diet quality, exercise habits, and genetic factors

Loading phase: For patients without neurological involvement, the standard regimen is 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks (total of six injections)

GLP-1 agonists work primarily through appetite suppression and slower gastric emptying