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Chronic Conditions: Individuals with chronic conditions that affect B12 absorption, such as pernicious anemia or gastrointestinal disorders, may need regular injections throughout their lives

This suggests that all forms of vitamin B12 methylcobalamin, aquacobalamin, and hydroxocobalamin interact with these biological agents by breaking Co-C or Co-O bonds, except for cyanocobalamin

403 In nonmutated cases, TET2 loss or DNMT3A overexpression created an alternative silencing mechanism via de novo DNA methylation, mimicking the repressive H3K27me3 state