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Future directions include approaches to personalized medicine, together with pharmacogenomics, and carefully planned research in various populations

(15) After inducing diabetic osteoporosis through a high fat diet and streptozotocin, light and scanning electron microscopy revealed evidence of bone deterioration via the upregulation of nuclear factor kappa-B ligand (RANKL) and downregulation of pro-osteogenic markers OPG and osteocalcin

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Adverse events leading to permanent discontinuation of treatment occurred in 6% of those on semaglutide and 1% of those on placebo