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While the largest percentage of intracellular iron is tightly bound to or incorporated into proteins as a cofactor or for storage, small portion of intracellular iron resides in the cytosol and intracellular organelles (e.g., lysosomes) and constitutes a redox-active liable iron pool, which regulates programmed cell death including ferroptosis 42

542 48C reduces mitochondrial ROS production in peripheral neutrophils, decreasing plasma cell expansion and autoantibody production in lupus-prone mice

Patient education should cover administration techniques for injectable formulations, proper storage requirements for peptide stability, and expected timelines for potential therapeutic effects based on preclinical data and limited clinical experience

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