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The UPR is initiated through three sensors: the protein kinase RNA-like ER kinase (PERK), the inositol requiring enzyme-1 (IRE-1), and the activating transcription factor-6 (ATF-6)
Fatty acid oxidation-induced HIF-1 activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH
and Brown, B.I
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