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David Maussang1, Jaap Rip2, Joan van Kregten2, Angelique van den Heuvel2, Susanne van der Pol3, Burt van der Boom2, Arie Reijerkerk 2, Linda Chen 2, Marco de Boer 2, Pieter Gaillard 4, Helga de Vries 3
The human CTR was modified to contain an N-terminal Flag tag epitope and a C-terminal 8 histidine tag epitope, each flanked by a HRV 3 C protease cleavage sites
This ensures safety and efficacy, minimizing the inherent risks associated with invasive procedures
PTH1R has the longest ECL1, but it is unstructured in both LA-PTHPTH1RG s 19 and ePTHPTH1R 37 structures, probably owing to the great mobility of PTH1Rs ECD and specific binding mode, consistent with the mutagenesis studies
Impairment of hepatic PC synthesis has been linked to hepatic lipid accumulation since it affects very-low-density lipoprotein (VLDL) production and secretion
