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The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality
But an individual doesnt lose all expected weight at the four-week or three-month mark
Short-acting drugs include exenatide twice daily, lixisenatide once daily and oral semaglutide once daily, while long-acting drugs include liraglutide, semaglutide, exenatide, albiglutide and dulaglutide all being administered once weekly