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High stress and high cortisol can suppress thyroid function and prevent the body from converting T4 into the active T3 hormone
The paracetamol study used to test this is a useful reference point
[3] Thymosin Beta 4: A Multi-Functional Regenerative Peptide
doi: 10.1101/2023.05.05.539417 152
For instance, synthetic FXR agonists such as obeticholic acid (OCA) can bind to allosteric pockets within the LBD, stabilizing distinct coactivator interfaces by enhancing specific dynamic coupling between helix 5 and helix 7, thereby generating gene expression profiles different from those induced by endogenous BAs (43)
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