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To fully understand GLP-1RAs effects on bone metabolism in a range of patient groups, particularly regarding osteoporosis and fracture risk management, more randomized controlled studies are necessary (69)

As observed in our results, nausea could be the most common complication of GLP1-Ras therapeutic plans, after constipation, and abdominal pain [60]

5,6 Additionally, high glucose levels negatively impact osteoblast function, contributing to bone defects partly through the production of advanced glycation end-products (AGEs), which upregulates sclerostin, an inhibitor of osteoblast activity

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How comfortable are you with having a clear escalation plan readily available