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TREX2 degrades cytoplasmic dsDNA, thereby inhibiting the activation of the cGAS/STING pathway, blocking the release of type I interferons and the apoptosis pathway, and thus maintaining the survival of tumor cells [126]
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The timeframe of the search extended up to July 2025, ensuring incorporation of the most recent evidence
4.3 Association with cancer-associated fibroblasts and exhausted immune microenvironment Spatial transcriptomic analyses and clinical correlation studies further support a broader immunomodulatory role for ACSL4
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