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doi: 10.1056/NEJMoa1607141 18 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al
A 17% Reduction in Overall Cancer Risk A landmark study published in JAMA Oncology (Dai H et al., August 2025), drawing on data from 14 health systems encompassing approximately 20 million patients, found that adults with obesity who were prescribed GLP-1 receptor agonists had a 17% lower risk of developing cancer compared to carefully matched non-users
Health decline is often a surprise Oxidative stress builds quietly, especially in high-performing adults Dark spots from sun exposure Looking more tired than you feel Alcohol hits harder than it used to You feel swollen or puffy more often Focus requires more effort Caffeine feels less effective Getting run down more easily General sense of being less bulletproof Its easy to just blame aging. But many of these changes, like how your skin looks and feels, are due to oxidative stress
While afamelanotide offers significant benefits for patients with specific conditions, the misuse of Melanotan II underscores the need for careful regulation and public education
Choosing an alternative doesnt mean giving up on resultsit means finding an approach that better fits your body, lifestyle, and preferences
