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Hyperglycemia is responsible for the generation of advanced glycation end products (AGEs) that can damage the kidney through receptor (RAGE)-dependent and -independent mechanisms [55]
However, until randomized clinical trials of these pharmacologic tools for obesity and metabolic dysfunction evaluate asthma outcomes as a primary endpoint, the costly management of comorbid asthma in adults with obesity will still heavily rely on the paradigm of inhaled ICS with or without LABA
On paper that is a modest way to lower blood sugar
We are committed to going above and beyond when it comes to safety
Dose escalation works for many patients because higher concentrations reactivate appetite suppression and metabolic effects that have plateaued
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