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Theres currently no convincing evidence for avoiding or delaying GLP-1 RAs out of concern for diabetic retinopathy progression

Tirzepatide received its first FDA approval in 2022

ARV-471, which selectively degrades estrogen receptor , is in phase I/II trials for advanced breast cancer (NCT05573555)

Lifestyle modification including weight loss, regular physical activity, and a balanced diet remains the cornerstone of managing fatty liver disease, with no specific supplements currently recommended as standard treatment

Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1alpha-mediated antioxidant capacity in mice