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MMPs normally regulate collagen degradation, with MMP-1 specifically implicated in the initiation of collagen fragmentation. A 2024 study found that elevated MMP-1 levels contribute to aging skin, causing in mice: A 2016 study showed that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration. Researchers attributed this as one mechanism by which the peptide increased collagen and elastin production

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Pregnant and breastfeeding women should avoid the peptide due to unknown effects on fetal and infant development

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The Regulatory Background In late 2023, the FDA placed 19 widely used peptides on its Category 2 restricted list, effectively barring compounding pharmacies from preparing them