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Retrospective EHR-based studies can capture real-world associations, yet they are especially vulnerable to residual confounding, treatment-selection bias, differences in healthcare engagement, and unmeasured disease biology
Importantly, unlike monotherapy with pure glucagon agonists, retatrutide did not cause worsening of glycemic control the concurrent GLP-1 and GIP activity effectively offset any hyperglycemic tendency from glucagon receptor activation
2025 Mar 6;135(9):e188314
More recently, though, its become a buzzworthy skin care ingredient, too
How long does L-carnitine take to show results
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