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Indeed, the fact that administration of phenformin can induce lactic acidosis, while metformin does not, suggests that these two biguanides act through different pathways ( Various in vitro and in vivo studies performed in different types of tumors, highlighted the ability of phenformin to reduce cancer cell proliferation strongly than metformin (Janzer et al., 2014)

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But those same receptors exist elsewhere in body, including the liver and the pancreas

DOI: 10.1016/j.freeradbiomed.2010.12.029 50