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About this article Cite this article Lei, C., Chen, Z., Ma, C

Secondly, metformin activates adenosine monophosphate (AMP)-activated kinase (AMPK), the master regulator of energy utilisation by cells

According to American Thyroid Association guidelines, treatment is typically initiated when TSH rises above 10 mIU/L or when TSH is between 4.5-10 mIU/L with symptoms or positive thyroid antibodies