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452,453 Inhibition of CDK4 by Flavopiridol or PD-0332991 significantly attenuated HFD-induced hepatic steatosis and fibrosis in mice, indicating that targeting CDK4 might be an appropriate strategy for resolving liver fibrosis
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Other potential side effects include hemolytic anemia, particularly in individuals with G6PD deficiency, and various gastrointestinal and respiratory symptoms such as abdominal pain, dry mouth, and nasal congestion
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