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In Phase 1 detoxification, liver enzymes (primarily the cytochrome P450 family) process these toxins, often making them even more reactive and dangerous in the short term

Focus of Cellular Alteration Introduction Foci of cellular alteration are common in rodent studies greater than duration of twelve months and may be seen in short duration toxicity studies following exposure to certain xenobiotics

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Healthy cells maintain a remarkable GSH to GSSG ratio exceeding 100:1