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Cardiovascular safety may be assessed either before or after authorisation, depending on the indication and the risk profile of the medicine this is determined on a case-by-case basis and is not universally required pre-authorisation, particularly for obesity indications
Rather, it reflects complex physiological adaptations as the body approaches a new metabolic equilibrium
Zhao X, Huang K, Zheng M, Duan J
(To counter this, some doctors prescribe phentermine on and off so patients can take a break in between treatment cycles)
If this is the case, your doctor will likely advise against taking GLP-1 medications
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