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MC4R knockout studies have confirmed MC4R dependence of the anorectic component while establishing that MC3R plays a modulatory rather than primary role in MT-II-induced anorexia
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This has been shown in a study published in the Journal of Hormone and Metabolic Research , where participants given recombinant human growth hormone showed an increase in IGF-1 levels and decreased abdominal fat after 26 weeks of treatment: Administration of recombinant human growth hormone (rhGH) in obesity has been known to lead to a decrease in visceral adiposity and an increase in lean body mass
Whether that translates into additive weight loss in humans is the open empirical question
More advanced stacks incorporate Ipamorelin (0.1-0.2 mg) with CJC-1295 no DAC (0.1-0.2 mg) taken together 2-3 times daily
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