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[16] These remain areas of investigation in humans and should not be interpreted as established risks at this stage

The pituitary GH axis recovers naturally during the 8-week off-cycle

People living in colder climates or with limited sun exposure: These individuals are at higher risk of Vitamin D deficiency

Refreezing after thawing Repeated freeze-thaw cycles damage peptide structure

[33] In chronic inflammatory bowel diseases, including Crohns disease, systematic reviews (including Cochrane reviews) have concluded that current randomized evidence is insufficient to support glutamine supplementation for inducing remission or modifying disease progression, and further well-powered clinical trials are required