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Fact : No, they are similar, but not the same
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Persistent or severe gastrointestinal symptoms while on GLP-1 therapy, such as severe nausea, vomiting, diarrhea, or severe abdominal pain, should prompt immediate medical evaluation
Both openings could provide access to the catalytic triad, as they have negative electrostatic potential and would attract the positively-charged N-terminus of the short bioactive peptide substrate (Rasmussen et al., 2002)
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