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Farilla, L
The population of interest comprised adults ( 18 years) with type 2 diabetes mellitus, mixed or unspecified diabetes populations (provided they were not exclusively composed of individuals with type 1 diabetes), or individuals with overweight or obesity, as defined by each included study
The milligram numbers are not directly comparable because each peptide has different potency per milligram at its target receptors
Trial-Reported Endpoints by Phase Trial Lancet 2021 Phase 2 Duration 26 weeks Population Overweight/obese, no T2D (n=706) Mean Weight Loss 10.8% at 4.5 mg vs 3.0% placebo Trial Lancet 2023 Phase 2 Duration 32 weeks Population T2D + obesity (n=92) Mean Weight Loss 8.1% cagrilintide alone
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