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Combined with clinical and genomic data, Roche could one day run virtual trials on in silico patient cohorts, accelerating drug candidate selection and dosing decisions
10.1186/s40824-023-00377-8 151 WangT.DongY.HuangZ.ZhangG.ZhaoY.YaoH.et al (2023c)
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As a result, the mechanisms underlying the impact of glucagon-like peptide-1 medications on the kidneys are unknown
One possible mechanism for the antineoplastic effect is the inhibition of IL-6 signalling pathways, which suppresses cellular invasion, and another is the abrogation of cell cycle progression in breast cancer cells (specifically MDA-MB-231 cells) via the down-regulation of important cyclins and CDK1 (160)
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