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Clin Pharmacokinet 11:250256 Forrest JAH, Adriaenssens P, Finlayson NDC, Prescott LF (1979) Paracetamol metabolism in chronic liver disease
As for vascular growth, which is highly correlated with tumor development, bilirubin inhibits ERK activity in damaged blood vessels, and because ERK activation is associated with the mitogenic stimulation-induced cyclin D1 expression (102, 103), the reduction of ERK activity caused by bilirubin may be responsible for the down-regulation of cyclinD1 by bilirubin after arterial injury
