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1 The ADA currently provides the following guidance and recommendations for GLP-1 RAs use in patients with T2D: 1 A GLP-1 RA or a sodium-glucose cotransporter2 (SGLT2) inhibitor with proven cardiovascular benefit is recommended in patients with T2D with established atherosclerotic cardiovascular disease (ASCVD) or indicators of high ASCVD risk

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Biological concern for PDAC based on preclinical studies In 2005, exenatide, the first GLP-1RA was marketed as treatment for T2D

These solicitations initially carried an aggressive due date of April 22nd, signaling the Pentagons intent to move at the speed of relevance. These topics were pre-released (and then delayed) on the 2026 DoW SBIR off-cycle solicitation (26.4)

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