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Intra- and extracellular iron remains in a dynamic balance
Currently Novo sells the drug in plastic injector pens
This spike is the signal to the pancreas for insulin release and the full signal to the brain
Others cancel each other out
An extension analysis of patients from Novo Nordisks own STEP1 trial found that one year after withdrawal of onceweekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained twothirds of their prior weight loss, with similar changes in cardiometabolic variables. If weight rebound is common after cessation of Wegovy and other GLP-1s, payers who cover these drugs may well need to plan for an enormous per-member expenditure for patients who stay on GLP-1s indefinitely
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