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A stack should only be considered when each component has a distinct purpose, the potential benefits outweigh the added risks, and the patient can be monitored appropriately

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Some pharmacies solve this by providing larger vials or higher concentrations for patients on maintenance doses

In a large RCT involving obese and prediabetic individuals, tirzepatide significantly delayed the onset of T2DM compared with placebo across multiple doses, with sustained benefits observed during long-term follow-up