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In an obese environment, many B2 cells are recruited into VAT through the action of the chemokine leukotriene B4 (LTB4) and its receptor LTB4R1, leading to tissue inflammation and the development of insulin resistance (163) ( Figure 3 )
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Microdosing GLP-1 for autoimmune conditions has emerged as a research interest based on the anti-inflammatory properties these peptides demonstrate in preclinical studies
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