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The plasma concentration vs
The mechanism of action involves binding to both GIP and GLP-1 receptors, which are naturally occurring incretin hormones that regulate glucose homeostasis and appetite
Additionally, tirzepatide may reduce the absorption of oral medications due to delayed gastric emptying, particularly affecting oral contraceptives, which may require alternative contraception methods for 4 weeks after initiation and each dose increase
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This doesnt mean semaglutide has stopped working completelybut its appetite-suppressing effect may feel weaker
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