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This synergistic mechanism explains clinical outcomes that neither receptor pathway produces independently
Wegovy is FDA-approved for weight management in people with a BMI (body mass index) of 30 or higher or 27 or higher if they have at least one weight-related medical condition, such as: High blood pressure ( hypertension ) Type 2 diabetes High cholesterol Sleep apnea Ozempic is FDA-approved for type 2 diabetes, but since it also contains semaglutide, its often prescribed off-label to help support weight management
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10.1126/science.134.3483.943 46 HolscherC
[43] analyzing a nationwide claims database, reported increased risks of new-onset depression, anxiety, and suicidal ideation among GLP-1 RA users, especially in women and younger individuals
