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Subcutaneous injection near injury sites or systemic administration both show effectiveness

It is characterized by the release of small portions of Ca 2+ and ROS from the mitochondria [184], prompting a short-term depolarization of the IMM that activates the ETC and inhibits ROS production by the mitochondria [185]

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any adjustments to escalation schedules would be protocol-specific and determined by the trial clinician, as established dose-modification data for retatrutide are not yet available