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Firmicutes are Gram-positive bacteria involved in fat production and storage (162)
Because fibroblast activity is a rate-limiting step in the closure and reorganization of experimental wounds, these cell-level observations are treated as a mechanistic starting point rather than an endpoint
Moreover, no studies have been undertaken in controlled circumstances to demonstrate whether a reduction in sulphotransferase activity causes increased paracetamol oxidation or increased propensity to paracetamol toxicity at either therapeutic or supra-therapeutic doses
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