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The answer is not simple
DiMauro, S., Schon, E
2005 Aug
Vivinus-Nbot M, Dainese R, Anty R, Saint-Paul MC, Nano JL, Gonthier N, Marjoux S, Frin-Mathy G, Bernard G, Hbuterne X, Tran A, Theodorou V, Piche T: Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells
By blocking NNMT, you're keeping visceral fat cells in a more reactive state even as overall caloric restriction continues
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