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designed the research
REFERENCES Everts ME, De Jong M, Lim CF, et al
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We previously demonstrated that intestinal GLP-1 release by the rare sugar D-allulose enhances insulin action via GLP-1R signaling in both lean and DIO mice ( Obese model mice (HFD-fed DIO mice, histamine H 1 receptor knockout mice) and rats (Zucker obese rat with a leptin receptor mutation) exhibit LP-specific hyperphagia and disruption of diurnal feeding rhythm ( In the future, the studies focusing on the central nerve system underlying the regulation of feeding and glucose metabolism by ISF-induced gastrointestinal distension and GLP-1 release will be important
Adherence data on daily oral dosing versus weekly injection is still accumulating, and daily regimens historically show lower long-term adherence than weekly ones across drug classes
