retatrutide phase 2 obesity nejm 2023 jastreboff SURMOUNT-1 (NEJM 2022) tested tirzepatide — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants First Retatrutide phase 3 data,
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