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NIH describes the cardiovascular implications as uncertain but concerning enough to discuss with a clinician if you have heart disease risk, high LDL cholesterol, kidney disease, or plan to use high doses for months
Diabetes 59 , 598-P (2009)
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Semaglutide GLP-1 is now recommended by the FDA for chronic weight management in patients with a BMI greater than 30 kg/m2 or 27 kg/m2 but having at least one obesity-related comorbidity
Post-marketing surveillance and case reports have documented isolated instances of patients reporting muscle pain, cramping, or weakness while taking GLP-1 medications, though establishing a direct causal relationship remains challenging
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